The use of Spironolactone for hair loss is a common trend among some dermatologist. What is the rationale for it? First a little about Spironolactone (brand name: Aldactone) is sometimes mentioned in forums focused on hair loss medication. It’s main function is to serve as a diuretic to reduce fluid in the body while sparing potassium levels. Physicians generally prescribe it for:

potassium deficiencies
hypertension
edemas
hyperaldosteronism

However, it is sometimes used as a hair loss medication in women, although this application is considered off-label.

Spironolactone for Hair Loss Treatment: Mechanism of Action in Pattern Baldness

Spironolactone has secondary chemical properties which can be beneficial for androgenic alopecia. Molecules of this drug compound are able to occupy androgen receptors on the hair follicles. This helps prevent these structures from the detrimental effects of DHT.

When DHT binds to sensitive androgen receptors, this can lead to the miniaturization of the follicles. However, Spironolactone can offer a measure of protection against this.

Typically, dosages range from 100-200mg/day.

When Can Spironolactone Be Used As a Drug For Treating Hair Loss?

If Spironolactone is considered for addressing androgenic alopecia, it is generally prescribed for women where the main cause of hair loss is attributed to excessive androgen hormones in the bloodstream.

Outside of this profile, physicians usually recommend topical treatments like Minoxidil 2% for females. Systemic interventions (i.e. oral drugs which can have an effect on the larger system) are reserved for cases when Minoxidil is not effective and blood tests have been performed which confirm higher than average levels of androgens.

While there are some studies which confirm that Spironolactone can be effective for these cases of female pattern baldness, the evidence overall is not conclusive.

Spironolactone For Hair Loss Treatment : Why Can’t Spironolactone Be Prescribed For Men?

Spironolactone is usually not prescribed as a medication for male pattern baldness . This is due to its possible side effects which include:

(1) sexual dysfunction

(2) breast enlargement

(3) blood pressure lowering

(4) Potassium abnormalities

Companies have developed a topical version of Spironolactone which is marketed to men. It is intended to prevent DHT induced miniaturization by blocking androgen receptors on the hair follicles. The ability of most over the counter products to actually affect hair follicles at their base is not supported by clinical studies. It is generally difficult to control the skin penetration level of these liquids and creams.

However, the use of FDA approved Finasteride is more likely to be effective as a counter agent to DHT. Finasteride blocks the enzyme alpha reductase which prevents the formation of DHT from testosterone.

Early Detection and Treatment As the Best Course of Action

Hair loss medications are more likely to be effective if the issue is addressed during the very early stages when the hair growth processes of follicles have not been completely undermined by the miniaturization effects of DHT.

All information contained within this site is for reference purposes only. You must consult and follow the directions of your physician and licensed health care professionals. Natural products have not been evaluated or approved by the FDA and are not intended to diagnose, treat, cure or prevent any health condition or disease

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